abstract：:The interactions of 6-8 ring hairpin polyamides (PAs) with the minor groove of DNA have been investigated extensively. More recent studies of large antiviral PAs (14-20 rings) active against small DNA tumor viruses lead to questions regarding the extent to which the DNA binding behaviors of the well studied, smaller P...

journal_title：Biochimie

authors： Song Y,Niederschulte J,Bales KN,Park AH,Bashkin JK,Dupureur CM

更新日期：2019-10-01 00:00:00

abstract：:Cell cycle-related and expression elevated protein in tumor (CREPT) is emerging as a novel cancer-related gene that is dysregulated in many kinds of malignancies. However, the expression and biological role of CREPT in glioma remains unclear. In the present study, we aimed to explore the potential function and regulat...

journal_title：Biochimie

authors： Wei M,Cao Y,Jia D,Zhao H,Zhang L

更新日期：2019-07-01 00:00:00

abstract：:The genus Populus is an effective model in tree genetics. This genus includes dioecious species and, recently, whole genome resequencing of P. trichocarpa and P. balsamifera enabled the identification of sex-linked regions and sex-associated single nucleotide polymorphisms (SNPs). These results created new opportuniti...

journal_title：Biochimie

authors： Melnikova NV,Kudryavtseva AV,Borkhert EV,Pushkova EN,Fedorova MS,Snezhkina AV,Krasnov GS,Dmitriev AA

更新日期：2019-07-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a heterogeneous group of breast cancer with one common feature: distinctly metastatic nature with higher rate of relapse and shorter survival compared with other subtypes of breast cancer. The epithelial to mesenchymal transition (EMT) is highly associated with cancer metastasis...

journal_title：Biochimie

authors： Liang L,Liu X,He J,Shao Y,Liu J,Wang Z,Xia L,Han T,Wu P

更新日期：2019-07-01 00:00:00

abstract：:The aim of the present work was to establish the thermodynamic and functional differences in the protein-protein interactions between the components of the P450-dependent mitochondrial (mit) and microsomal (mic) monooxygenase systems using 12 different isoforms of cytochromes P450 and two redox partners, NADPH-depende...

journal_title：Biochimie

authors： Yablokov EO,Sushko TA,Ershov PV,Florinskaya AV,Gnedenko OV,Shkel TV,Grabovec IP,Strushkevich NV,Kaluzhskiy LA,Usanov SA,Gilep AA,Ivanov AS

更新日期：2019-07-01 00:00:00

abstract：:The expression of serotonin (5-HT) in the retina was first reported in the sixties. The detection of vesicular monoamine transporter and serotonin receptors in several retinal cells confirm that 5-HT is playing a neuromodulatory role in this structure. Whereas signaling pathways activated by 5-HT receptor binding has ...

journal_title：Biochimie

authors： Masson J

更新日期：2019-06-01 00:00:00

abstract：:Virtually all brain circuits are physically embedded in a three-dimensional matrix of fibers that release 5-hydroxytryptamine (5-HT, serotonin). The density of this matrix varies across brain regions and cortical laminae, and it is altered in some mental disorders, including Major Depressive Disorder and Autism Spectr...

journal_title：Biochimie

authors： Janušonis S,Detering N

更新日期：2019-06-01 00:00:00

abstract：:The redox homeostasis of cytoplasm is maintained by a series of disulfide exchange reactions mediated by proteins belonging to the thioredoxin superfamily. Thioredoxin and thioredoxin reductase, being the major members of the family, play a key role in oxidative stress response of Staphylococcus aureus. In this report...

journal_title：Biochimie

authors： Bose M,Bhattacharyya S,Biswas R,Roychowdhury A,Bhattacharjee A,Ghosh AK,Das AK

更新日期：2019-05-01 00:00:00

abstract：:Thyroid peroxidase (TPO) is the key enzyme involved in thyroid hormone synthesis. Autoantibodies to TPO (TPOAbs) are a hallmark of autoimmune thyroid disease (AITD). Here, we highlight recent progress over several years in understanding TPO biochemistry and function in various pathologies. TPO undergoes complex post-t...

journal_title：Biochimie

authors： Godlewska M,Banga PJ

更新日期：2019-05-01 00:00:00

abstract：:Bacterial survive and respond to adverse changes in the environment by regulating gene transcription through two-component regulatory systems. In Salmonella Typhimurium the STM1485 gene expression is induced under low pH (4.5) during replication inside the epithelial host cell, but it is not involved in sensing or res...

journal_title：Biochimie

authors： Torrez Lamberti MF,Farizano JV,López FE,Martínez Zamora MG,Pescaretti MM,Delgado MA

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Fatty acids (FAs), and especially monounsaturated FAs (MUFAs) stimulate GLP-1 release. However, lipotoxicity is indicated in GLP-1 secreting cells following long-term exposure to elevated levels of saturated FAs (SFAs) in vivo and in vitro, where in vitro studies indicate that cosupplementation with MUFAs co...

journal_title：Biochimie

authors： Ntika S,Thombare K,Aryapoor M,Kristinsson H,Bergsten P,Krizhanovskii C

更新日期：2019-04-01 00:00:00

abstract：:The potent cytotoxicity of reactive oxygen species (ROS) can cause various diseases, however, it may also serve as a powerful chemotherapeutic strategy capable of killing cancer cells. Oxalomalate (OMA, α-hydroxy-β-oxalosuccinic acid), a tricarboxylic acid intermediate, is a well-known competitive inhibitor of two cla...

journal_title：Biochimie

authors： Kim SH,Kil IS,Kwon OS,Kang BS,Lee DS,Lee HS,Lee JH,Park JW

更新日期：2019-03-01 00:00:00

abstract：:Lipid membranes have an essential role in most physiological processes including cell protection, cell-to-cell communication and regulation of intracellular signaling. These multiple roles of biological membranes prompted the study and the development of artificial lipid membranes with the primary aim to reconstitute ...

journal_title：Biochimie

authors： Penkauskas T,Preta G

更新日期：2019-02-01 00:00:00

abstract：:Kissing loop interactions (KLIs) are a common motif that is critical in retroviral dimerization, viroid replication, mRNA, and riboswitches. In addition, KLIs are currently used in a variety of biotechnology applications, such as in aptamer sensors, RNA scaffolds and to stabilize vaccines for therapeutics. Here we des...

journal_title：Biochimie

authors： Carr CE,Marky LA

更新日期：2019-02-01 00:00:00

abstract：:Binding of indoloquinolines with different aliphatic side chains to a parallel G-quadruplex derived from the MYC promoter sequence was characterized by optical and calorimetric measurements. ITC experiments performed at different temperatures enabled the determination of molar heat capacity changes upon quadruplex bin...

journal_title：Biochimie

authors： Funke A,Weisz K

更新日期：2019-02-01 00:00:00

abstract：:Chronic hypobaric hypoxia induced muscle atrophy results in decreased physical performance at high altitude. Curcumin has been shown to have muscle sparing effects under cachectic conditions. However, the protective effects of curcumin under chronic hypobaric hypoxia have not been studied till now. Therefore, the pres...

journal_title：Biochimie

authors： Chaudhary P,Sharma YK,Sharma S,Singh SN,Suryakumar G

更新日期：2019-01-01 00:00:00

abstract：:Parkinson's disease (PD), a neurodegenerative disorder, is characterized by a loss of dopaminergic neurons in the substantia nigra (SN) of the brain and it is well known that the pathogenesis of PD is related to a number of risk factors including oxidative stress. Antioxidant 1 (ATOX1) protein plays a crucial role in ...

journal_title：Biochimie

authors： Eum WS,Shin MJ,Lee CH,Yeo HJ,Yeo EJ,Choi YJ,Kwon HJ,Kim DS,Kwon OS,Lee KW,Han KH,Park J,Kim DW,Choi SY

更新日期：2019-01-01 00:00:00

abstract：:Extracellular Hsp70 (eHsp70) can activate immune cells via Toll-like receptors (TLR) 2 and 4, and induce cytokine synthesis. The aim of this study was to explore inflammation-associated effects of eHsp70 alone and in combination with cigarette smoke extract (CSE) in primary bronchial epithelial cells. We assessed IL-6...

journal_title：Biochimie

authors： Hulina-Tomašković A,Heijink IH,Jonker MR,Somborac-Bačura A,Grdić Rajković M,Rumora L

更新日期：2019-01-01 00:00:00

abstract：:The secretome produced by cells within the bone marrow is significant to homeostasis. The bone marrow, a well-studied organ, has multiple niches with distinct roles for supporting stem cell functions. Thus, an understanding of mediators involved in the regulation of stem cells could serve as a model for clinical probl...

journal_title：Biochimie

authors： Eltoukhy HS,Sinha G,Moore CA,Gergues M,Rameshwar P

更新日期：2018-12-01 00:00:00

abstract：:Personalized and regenerative medicine is an emerging therapeutic strategy that is based on cell biology and biomedical engineering used to develop biological substitutes to maintain normal function or restore damaged tissues and organs. The secretory capacities of different cell types are now explored as such possibl...

journal_title：Biochimie

authors： Gaceb A,Barbariga M,Özen I,Paul G

更新日期：2018-12-01 00:00:00

abstract：:The x-ray structure of the monotopic membrane protein (S)-mandelate dehydrogenase (MDH) from Pseudomonas putida reveals an inherent flexibility of its membrane binding segment that might be important for its biological activity. The surface of MDH exhibits a concentration of the positive charges on one side and the ne...

journal_title：Biochimie

authors： Sukumar N,Liu S,Li W,Mathews FS,Mitra B,Kandavelu P

更新日期：2018-11-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most diagnosed cancer in the western world, affecting 1 out of approximately 22 people in their lifetime. Several epidemiological studies suggest a positive association between high plasma cholesterol levels and colorectal cancer. However, the molecular mechanisms by which choleste...

journal_title：Biochimie

authors： Warns J,Marwarha G,Freking N,Ghribi O

更新日期：2018-10-01 00:00:00

abstract：:Some oxysterols resulting either from enzymatic oxidation or autoxidation of cholesterol are associated with age-related diseases including neurodegenerative diseases. Among these oxysterols, 7β-hydroxycholesterol (7β-OHC) is often found at increased levels in patients. It is therefore important to identify molecules ...

journal_title：Biochimie

authors： Zarrouk A,Ben Salem Y,Hafsa J,Sghaier R,Charfeddine B,Limem K,Hammami M,Majdoub H

更新日期：2018-10-01 00:00:00

abstract：:Recently we have found that cytokine IL-2 and innate immunity protein Tag7 activate cytotoxic lymphocytes that kill HLA-negative tumor cells, inducing both apoptosis and necroptosis. Here we decrypt the processes, taking part in necroptosis execution after FasL-Fas interaction. Necroptosis begins with RIPK1 activation...

journal_title：Biochimie

authors： Sharapova TN,Romanova EA,Sashchenko LP,Yashin DV

更新日期：2018-09-01 00:00:00

abstract：:Diacylglycerol kinase (DGK) is a lipid-metabolizing enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). DGKδ is highly expressed in the skeletal muscle, and a decrease in DGKδ expression increases the severity of type 2 diabetes. However, the role of DGKδ in myogenic differentiation is st...

journal_title：Biochimie

authors： Sakai H,Murakami C,Matsumoto KI,Urano T,Sakane F

更新日期：2018-08-01 00:00:00

abstract：:Clustered apurinic/apyrimidinic (AP) sites are more cytotoxic than isolated AP lesions because double strand breaks (DSB) can be formed during repair of closely positioned bistranded AP sites. Formation of DSB due to simultaneous cleavage of bistranded AP sites may be regulated by proteins specifically interacting wit...

journal_title：Biochimie

authors： Ilina ES,Khodyreva SN,Lavrik OI

更新日期：2018-07-01 00:00:00

abstract：:Sticholysin II (StII) is a pore-forming toxin of biomedical interest that belongs to the actinoporin protein family. Sticholysins are currently under examination as an active immunomodulating component of a vaccinal platform against tumoral cells and as a key element of a nucleic acids delivery system to cell cytosol....

journal_title：Biochimie

authors： Soto C,Bergado G,Blanco R,Griñán T,Rodríguez H,Ros U,Pazos F,Lanio ME,Hernández AM,Álvarez C

更新日期：2018-05-01 00:00:00

abstract：:Peptidase family S46 consists of two types of dipeptidyl-peptidases (DPPs), DPP7 and DPP11, which liberate dipeptides from the N-termini of polypeptides along with the penultimate hydrophobic and acidic residues, respectively. Their specificities are primarily defined by a single amino acid residue, Gly673 in DPP7 and...

journal_title：Biochimie

authors： Nemoto TK,Bezerra GA,Ono T,Nishimata H,Fujiwara T,Ohara-Nemoto Y

更新日期：2018-04-01 00:00:00

abstract：:With the increase of multidrug resistance, novel anti-leukemia agents with diverse mechanisms of action are required to address this challenge. NK-18, the core region of mammalian derived protein NK-lysin, effectively inhibited the viability of both multidrug resistant and sensitive leukemia cell lines. Meanwhile, thi...

journal_title：Biochimie

authors： Yan J,Liang X,Bai C,Zhou L,Li J,Wang K,Tang Y,Zhao L

更新日期：2018-04-01 00:00:00

abstract：:Neprilysin is also known as skin fibroblast-derived elastase, and its up-regulation during aging is associated with impairments of the elastic fiber network, loss of skin elasticity and wrinkle formation. However, information on its elastase activity is still limited. The aim of this study was to investigate the degra...

journal_title：Biochimie

authors： Mora Huertas AC,Schmelzer CEH,Luise C,Sippl W,Pietzsch M,Hoehenwarter W,Heinz A

更新日期：2018-03-01 00:00:00

abstract：:About 150 participants attended the symposium organised at the Palais de la Bourse in Bordeaux, France on September 22-23, 2017. Thirty speakers from all over the world delivered lectures covering selection processes, aptamer chemistry and innovative applications of these powerful tools that display major advantages o...

journal_title：Biochimie

authors： Toulmé JJ,Azéma L,Darfeuille F,Dausse E,Durand G,Paurelle O

更新日期：2018-02-01 00:00:00

abstract：:The present review deals with the place of single chain oligonucleotide ligands (aptamers) in affinity chromatography applied to proteins. Aptamers are not the only affinity ligands available but they represent an emerging and highly promising route that advantageously competes with antibodies in immunopurification pr...

journal_title：Biochimie

authors： Perret G,Boschetti E

更新日期：2018-02-01 00:00:00

abstract：:The multisubunit Mediator is an evolutionary conserved transcriptional coregulatory complex in eukaryotes. It is needed for the transcriptional regulation of gene expression in general as well as in a gene specific manner. Mediator complex subunits interact with different transcription factors as well as components of...

journal_title：Biochimie

authors： Ranjan A,Ansari SA

更新日期：2018-01-01 00:00:00

abstract：:Thraustochytrium is a marine protist producing a specific profile of nutritionally important fatty acids, including very long chain polyunsaturated fatty acids (VLCPUFAs) docosahexaenoic acid (DHA, 22:6n-3), even chain saturated fatty acids (SFAs) palmitic acid (16:0), and odd chain SFAs pentadecanoic acid (15:0). To ...

journal_title：Biochimie

authors： Zhao X,Qiu X

更新日期：2018-01-01 00:00:00

abstract：:Protein-induced DNA bridging and looping is a common mechanism for various and essential processes in bacterial chromosomes. This mechanism is preserved despite the very different bacterial conditions and their expected influence on the thermodynamic and kinetic characteristics of the bridge formation and stability. O...

journal_title：Biochimie

authors： Tardin C

更新日期：2017-11-01 00:00:00

abstract：:Sphingosine is a natural sphingolipid found in membranes of all eukaryotic cells. In addition to its functions in cell signaling, sphingosine has broad-spectrum antimicrobial properties. Sphingosine's role as an antimicrobial is important in tissues such as the skin and respiratory epithelium. Reduction in the normal ...

journal_title：Biochimie

authors： Martin GE,Boudreau RM,Couch C,Becker KA,Edwards MJ,Caldwell CC,Gulbins E,Seitz A

更新日期：2017-10-01 00:00:00

abstract：:Bacterial type II fatty acid synthesis (FASII) is a target for novel antibiotic development. All bacteria encode for mechanisms to incorporate exogenous fatty acids, and some bacteria can use exogenous fatty acids to bypass FASII inhibition. Bacteria encode three different mechanisms for activating exogenous fatty aci...

journal_title：Biochimie

authors： Yao J,Rock CO

更新日期：2017-10-01 00:00:00

abstract：:Antimicrobials targeting the fatty acid synthesis (FASII) pathway are being developed as alternative treatments for bacterial infections. Emergence of resistance to FASII inhibitors was mainly considered as a consequence of mutations in the FASII target genes. However, an alternative and efficient anti-FASII resistanc...

journal_title：Biochimie

authors： Morvan C,Halpern D,Kénanian G,Pathania A,Anba-Mondoloni J,Lamberet G,Gruss A,Gloux K

更新日期：2017-10-01 00:00:00

abstract：:Experimental Lyme arthritis provides a mouse model for exploring the development of pathology following infection of C3H mice with Borrelia burgdorferi. Infected mice develop a reliable inflammatory arthritis of the ankle joint with severity that typically peaks around two to three weeks post-infection and then underg...

journal_title：Biochimie

authors： Brown CR,Dennis EA

更新日期：2017-10-01 00:00:00

abstract：:The hepatitis E virus (HEV) is the most common cause of acute hepatitis worldwide. Although HEV is a small, naked RNA virus, HEV particles become associated with lipids in the blood of infected patients and in the supernatant of culture systems. The egress of these particles from cells implies the exocytosis pathway b...

journal_title：Biochimie

authors： Chapuy-Regaud S,Dubois M,Plisson-Chastang C,Bonnefois T,Lhomme S,Bertrand-Michel J,You B,Simoneau S,Gleizes PE,Flan B,Abravanel F,Izopet J

更新日期：2017-10-01 00:00:00